Table 4.
List of differentially expressed genes at the third trimester of pregnancy associated with changes in depressive symptoms (from the third trimester to 2 months postpartum) at 5% FDR.
| Symbol | GnRHa_estradiol | Probe | Chr | P value_EPDSv2 | FDR_EPDSv2 | logFC_diffEPDSv2 | P value_diffEPDSv2 | FDR_diffEPDSv2 | logFC_PPD | P value_PPD | FDR_PPD | logFC_Dep | P value_Dep | FDR_Dep |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LOC100132062 | 100132062 | NA | 2.74E-59 | 3.52E-55 | −0.09642385 | 1.86E-08 | 1.99E-05 | −2.0794307 | 1.58E-33 | 1.01E-29 | 2.03759936 | 5.40E-19 | 6.94E-15 | |
| GSTA7P | 730152 | 6 | 0.147252834 | 0.999797241 | 0.072537172 | 0.000661439 | 0.094343313 | 2.272172 | 1.65E-36 | 2.12E-32 | −1.865593 | 1.46E-14 | 9.40E-11 | |
| SLC12A1 | x | 6557 | 15 | 0.738374001 | 0.999797241 | −0.143662302 | 3.04E-23 | 3.91E-19 | −1.5148531 | 3.68E-24 | 1.58E-20 | 1.52947173 | 1.01E-10 | 4.31E-07 |
| FAM3B | 54097 | 21 | 0.000506343 | 0.073862832 | −0.081062951 | 4.36E-07 | 0.000357438 | −1.2068425 | 2.86E-11 | 6.13E-08 | 1.29211562 | 4.09E-08 | 0.00013115 | |
| RAP1GAP | 5909 | 1 | 0.000417001 | 0.066086904 | −0.084706388 | 1.69E-09 | 2.71E-06 | −0.7001112 | 1.09E-07 | 0.0001401 | 0.95024605 | 2.17E-06 | 0.00537669 | |
| MYOM2 | 9172 | NA | 0.558974564 | 0.999797241 | 0.045488778 | 0.002563317 | 0.19942602 | 0.66107629 | 8.04E-07 | 0.00077909 | −0.9456007 | 2.51E-06 | 0.00537669 | |
| RNF182 | 221687 | 6 | 0.983664265 | 0.999797241 | −0.08587623 | 5.84E-07 | 0.000441361 | −0.8205146 | 1.54E-08 | 2.47E-05 | 0.9490668 | 7.75E-06 | 0.01421399 | |
| HBZ | 3050 | 16 | 1.81E-13 | 7.73E-10 | 0.08198997 | 3.96E-11 | 8.47E-08 | 1.24062397 | 8.58E-19 | 2.75E-15 | −0.8915749 | 1.76E-05 | 0.02832105 | |
| PRSS33 | x | 260429 | 16 | 1.82E-06 | 0.00101726 | −0.017543158 | 0.204453261 | 0.961442886 | 0.66940149 | 7.80E-07 | 0.00077909 | −0.8128711 | 3.66E-05 | 0.05215136 |
| IFI27 | 3429 | NA | 0.491717731 | 0.999797241 | 0.088816879 | 2.79E-09 | 3.98E-06 | 1.07939383 | 5.46E-16 | 1.40E-12 | −0.7622081 | 8.16E-05 | 0.10472842 | |
| PTGDR2 | 11251 | 11 | 0.07345098 | 0.999797241 | −0.009817193 | 0.48417276 | 0.999245113 | 0.68209765 | 9.10E-07 | 0.00077909 | −0.7728273 | 9.83E-05 | 0.11468724 | |
| C4BPA | x | 722 | 1 | 2.91E-10 | 6.22E-07 | −0.051502467 | 3.73E-06 | 0.002174605 | −0.6400513 | 6.58E-06 | 0.00384058 | 0.82369396 | 0.00010817 | 0.11571456 |
| MAPK8IP1P2 | 644172 | NA | 0.038012933 | 0.90051655 | 0.000303088 | 0.987530803 | 0.999245113 | −0.9800435 | 2.22E-06 | 0.001679 | 0.97855722 | 0.00012366 | 0.12211055 | |
| SLC35F1 | 222553 | 6 | 0.012780901 | 0.533803126 | −0.070659963 | 1.20E-07 | 0.000110253 | 0.89950392 | 2.61E-10 | 4.78E-07 | −0.7774074 | 0.00015966 | 0.14639261 | |
| CMBL | 134147 | 5 | 0.475930622 | 0.999797241 | −0.033792967 | 0.036959174 | 0.639413638 | −0.7375122 | 3.29E-06 | 0.00211048 | 0.74263329 | 0.00044747 | 0.36562804 | |
| SFRP2 | 6423 | 4 | 0.422133267 | 0.999797241 | −0.019762377 | 0.182110005 | 0.957043264 | −0.5742315 | 2.74E-05 | 0.01256455 | 0.70217911 | 0.00045572 | 0.36562804 | |
| GALNT15 | 117248 | 3 | 0.661378861 | 0.999797241 | 0.005687522 | 0.71076802 | 0.999245113 | 0.73127667 | 5.79E-07 | 0.00067543 | −0.678052 | 0.00076939 | 0.57668405 | |
| ALOX15 | 246 | 17 | 0.006381561 | 0.367354704 | −0.004218688 | 0.757440501 | 0.999245113 | 0.57396501 | 1.79E-05 | 0.00886108 | −0.6573506 | 0.00080862 | 0.57668405 | |
| RAVER2 | 55225 | 1 | 0.122015102 | 0.999797241 | 0.026473215 | 0.082808829 | 0.811263458 | 0.73076056 | 8.57E-07 | 0.00077909 | −0.6602258 | 0.00122902 | 0.83036233 | |
| HES6 | 55502 | 2 | 0.616984359 | 0.999797241 | −0.023906291 | 0.104221966 | 0.860937819 | 0.78046567 | 2.83E-08 | 4.04E-05 | −0.5834678 | 0.00300491 | 0.99997367 | |
| SPTBN4 | x | 57731 | 19 | 0.853952516 | 0.999797241 | 0.04814081 | 0.003906481 | 0.251997482 | 0.84111298 | 1.57E-06 | 0.00125925 | −0.5715084 | 0.01091626 | 0.99997367 |
| FIBCD1 | 84929 | 9 | 0.01477133 | 0.571957401 | 0.054000943 | 0.00016668 | 0.038903107 | 0.72292732 | 2.77E-06 | 0.00197483 | −0.5574507 | 0.007439 | 0.99997367 | |
| OLR1 | 4973 | 12 | 0.137268091 | 0.999797241 | −0.040708626 | 0.002826989 | 0.21222253 | −0.6437111 | 3.00E-06 | 0.00202536 | 0.62579802 | 0.00157598 | 0.99997367 | |
| FAM83A | 84985 | 8 | 6.56E-06 | 0.003005253 | 0.035483408 | 0.024659247 | 0.565101277 | 0.68242078 | 3.88E-06 | 0.00237108 | −0.4020439 | 0.04915913 | 0.99997367 | |
| RSAD2 | 91543 | 2 | 0.001262375 | 0.135042605 | −0.003101777 | 0.802973454 | 0.999245113 | 0.55847735 | 1.04E-05 | 0.00581173 | −0.423053 | 0.02966682 | 0.99997367 | |
| NA | 654341 | NA | 0.040041391 | 0.918606088 | 0.043642091 | 0.002347612 | 0.194240656 | −0.5985625 | 1.47E-05 | 0.00779562 | 0.62713957 | 0.00188074 | 0.99997367 | |
| DDX11L10 | 100287029 | 16 | 0.027398604 | 0.771306761 | 0.019363117 | 0.196566971 | 0.961362007 | −0.7114069 | 1.52E-05 | 0.00779562 | 0.60633309 | 0.00556542 | 0.99997367 | |
| NCAPG2 | 54892 | NA | 0.118956575 | 0.999797241 | 0.035486631 | 0.013137006 | 0.436890536 | 0.60702078 | 2.18E-05 | 0.01035033 | −0.4730099 | 0.01883019 | 0.99997367 | |
| DEFA1B | 728358 | 8 | 2.73E-09 | 3.90E-06 | −0.082334647 | 2.83E-08 | 2.80E-05 | 0.53566102 | 5.17E-05 | 0.02287903 | −0.505308 | 0.00958881 | 0.99997367 | |
| MMP8 | 4317 | 11 | 0.093862874 | 0.999797241 | −0.042863638 | 0.001119109 | 0.133018019 | −0.5140184 | 6.88E-05 | 0.02943342 | 0.50413614 | 0.00877009 | 0.99997367 | |
| NEBL | 10529 | 10 | 0.177260886 | 0.999797241 | −0.030514743 | 0.029510787 | 0.604610542 | 0.59512746 | 7.33E-05 | 0.03037117 | −0.6234225 | 0.00358599 | 0.99997367 | |
| OR8U8 | 504189 | NA | 7.64E-05 | 0.020856842 | 0.042692465 | 0.000391896 | 0.065334587 | 0.51621139 | 9.78E-05 | 0.03924713 | −0.3413738 | 0.08193914 | 0.99997367 | |
| CLC | 1178 | 19 | 0.04198233 | 0.934015898 | 0.001050171 | 0.933703936 | 0.999245113 | 0.48764167 | 0.00010431 | 0.0405769 | −0.5586975 | 0.00285235 | 0.99997367 | |
| SMIM1 | 388588 | 1 | 1.08E-05 | 0.004463077 | −0.046924669 | 0.000526408 | 0.081415689 | 0.52234014 | 0.00011953 | 0.04456932 | −0.2791593 | 0.15879646 | 0.99997367 | |
| ISG15 | 9636 | 1 | 0.335644265 | 0.999797241 | 0.016722871 | 0.173604797 | 0.957043264 | 0.49763474 | 0.00012152 | 0.04456932 | −0.3898466 | 0.04277624 | 0.99997367 | |
| KIAA1324L | 222223 | 7 | 0.940093172 | 0.999797241 | 0.011875341 | 0.433620456 | 0.999245113 | −0.6272798 | 0.0001271 | 0.04532091 | 0.603388 | 0.00521569 | 0.99997367 | |
| ZFP57 | x | 346171 | 6 | 0.688934236 | 0.999797241 | 0.113752939 | 9.57E-12 | 3.07E-08 | 0.6292577 | 0.00014379 | 0.04988752 | −0.6042326 | 0.0056805 | 0.99997367 |
| TMEM176B | x | 28959 | 7 | 0.003678342 | 0.266546287 | −9.93E-05 | 0.993610049 | 0.999245113 | 0.48636354 | 0.00014793 | 0.04997309 | −0.6027717 | 0.0021531 | 0.99997367 |
EPDS Edinburgh Postnatal Depression Scale symptoms at 2 months postpartum, diffEPDS difference in EPDS symptoms from the third trimester of pregnancy to 2 months postpartum, PPD EPDS symptoms in the PPD group, Dep EPDS symptoms in the depression group, GnRHa_estradiol genes associated with estradiol in the GnRHa study, FDR P values after false discovery rate multiple testing.