Figure 4.

MRI images in 51-year-old patient with triple negative breast cancer. (A) Proton ${\text{T}}_1$w fat suppressed (FS) anatomical image. The area in red is the ROI containing the lesion. (B) Different slice of the same volume showing the control ROI (blue region) in the contralateral breast. (C) Dynamic ${}^1$H signal enhancement shows high uptake of contrast agent (CA) in a 645-voxel-ROI that includes the tumor (red ROI in panel A) compared to a 100-voxel control ROI in contralateral healthy fibroglandular tissue (blue region in panel B) (D) Sodium image, corresponding to the ${}^1$H ${\text{T}}_1$w in panel A, acquired with a FLORET sequence showing hyperintensity in the tumor. (E) Sodium image in which healthy contralateral tissue is visible, co-registered with the ${}^1$H ${\text{T}}_1$w image in (B). (F) Boxplot showing the distribution of ${}^{23}\text{Na}$ signal within the tumor and in the contralateral healthy fibroglandular tissue (control). Sodium signal intensity in the lesion is 2-fold higher than in the control.