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. 2021 Mar 4;6:20. doi: 10.1038/s41525-021-00184-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Distribution of ages at referral in the pediatric cohort (n = 281 probands). b Distribution of ages at referral in the adult cohort (n = 271 probands). Each data point represents a proband (blue = male; red = female) referred for the relevant panel. Filled black points indicate outliers (points beyond 1.5 times the interquartile range above the upper hinge [75th percentile] or below the lower hinge [25th percentile]). Abbreviated panels are as follows: ADTKD autosomal dominant tubulointerstitial kidney disease, aHUS/C3 GN atypical hemolytic uremic syndrome-C3 glomerulonephritis, Alport Alport syndrome, ARPKD autosomal recessive polycystic kidney disease, BORS branchio-oto renal syndrome, CAKUT congenital anomalies of the kidney and urinary tract, Nephrotic nephrotic syndrome, NPHP & ciliopathies nephronophthisis & related ciliopathies.