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. 2021 Feb 19;10:588517. doi: 10.3389/fcimb.2020.588517

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Copyright © 2021 Zhang, Wu, Yang, Chen, Liao, Zhu, Wu, Sun and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of berberine on diseases by regulating intestinal flora. 1. Berberine can activate TLR4/MyD88/NF-κB signal pathway to play an anti-inflammatory role, and increase the populations of Bacteroidetes, Clostridia, Lactobacillales, Prevotellaceae, Alloprevotella, Butyricimonas, Coprococcus, Ruminococcus, Lactobacillus, Akkermansia, Verrucomicrobia, reduce the populations of Bacteroidales, Lachnospiraceae, Rikenellaceae, Desulfovibrio, Streptococcaceae, Clostridiaceae, Prevotella, Proteus, Saccharibacteria, Deferribacteres, Actinobacteria, which affect the development of diabetes. 2. Berberine affects liver diseases by regulating FXR and NF-κB signaling pathways through intestinal flora. 3. Berberine down-regulate F:B (Firmicutes : Bacteroidetes) and up-regulate SCFA-producing bacteria Allobaculum, Bacteroides, Blautia, Butyricicoccus, Phascolarctobacterium, A. muciniphila and GLP-1R in obesity. 4. Berberine regulates hyperlipidemia by reducing Prevotella, Escherichia, Clostridium Sutterella and increase Bacteroides, Parabacteroides, Blautia, Enterobacter, Akkermansia, Escherichia-Shigella, Incertae sedis, Lachnospiraceae FCS020, Clostridium sensu stricto 1. 5. In Enteropatia, berberine enriched the relative abundance of Firmicutes and decreased Proteobacteria at the phylum level. Meanwhile, berberine increased the propotion of unclassified_f_Porphyromonadaceae, unclassified_f_Lachnospiraceae, Lactobacillus, unclassified_o_Clostridiales, Ruminococcus, Prevotella, Clostridium IV, and decreased Escherichia/Shigella at the genera level. 6. Berberine affect the development of Atherosclerosis by changing the amount of Verrucomicrobia, Akkermansia in Apoe (^−/−) mice fed a high-fat diet in the intestine.