Figure 5.
The chronic use of the 6 drugs combination reduces the energy expenditure and limits the loss of total fat mass in tumor-bearing mice. (a) Average oxygen consumption (VO2) values in the 6 drugs groups from non-tumor and tumor-bearing mice at days 0 and 21 of treatment, during a 24 h period composed of 12 h of fasting and 12 h of postprandial. (b,c) Delta of total fat (b) and lean (c) masses percentages at days 0 and 21 of evaluation. Data are expressed as means ± s.e.m. N = 1 independent experiment, 10 mice/group. Statistical analyses were performed with one-way ANOVA with Dunnet correction. 6 drugs: Orlistat + lonidamine + DON + growth hormone + insulin + indomethacin; ns: non-significant; *p < 0.05; ***p < 0.001.