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. 2021 Mar 4;12(3):247. doi: 10.1038/s41419-021-03525-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Distribution of NS, AK, and cSCC samples in the pseudo-time trajectory analysis. b Samples were highlighted by pseudo-time in the trajectory, which showed a progression from NS to AK then cSCC. c Co-expressed network calculated between TFs and genes among the cSCC progression-driven genes. Purple rectangle nodes represent TFs and plink elliptic nodes represent genes. d Rorα expression with regards to the trajectory pseudo-time. Rorα expression was significantly downregulated in cSCC group.