Table 3.

Multivariate Cox regression analysis for predictors of 1-year all cause death and MACE.

	Reduced EF			Preserved EF
Variable	Adjusted HR	95% CI	P-value	Adjusted HR	95% CI	P-value
(A) 1-year all cause death
CTO in a non-IRA	1.58	1.06–2.33	0.02	1.16	0.46–2.92	0.76
Age	1.02	1.00–1.04	0.03	1.07	1.04–1.10	<0.001
Anemia (Hb < 11 g/dL)	1.77	1.20–2.61	0.004	2.14	1.18–3.87	0.012
CKD	1.64	1.07–2.50	0.02	1.71	0.97–3.00	0.06
Previous stroke	1.10	0.67–1.81	0.71	1.93	0.87–4.27	0.11
Killip classification	2.20	1.88–2.58	<0.001	1.74	1.40–2.16	<0.001
(B) 1-year MACE
CTO in a non-IRA	1.67	1.14–2.46	0.009	0.70	0.26–1.93	0.49
Age	1.00	0.99–1.02	0.83	1.05	1.02–1.07	<0.001
Diabetes mellitus	1.37	0.97–1.95	0.07	1.92	1.22–3.00	0.005
Anemia (Hb < 11 g/dL)	1.26	0.81–1.95	0.31	2.29	1.30–4.03	0.004
CKD	2.05	1.33–3.13	0.001	1.37	0.85–2.22	0.20
Previous stroke	0.86	0.49–1.51	0.60	0.70	0.25–1.95	0.50
Killip classification	2.03	1.74–2.36	<0.001	1.70	1.40–2.08	<0.001

Multivariate Cox regression analysis for 1-year all-cause death was conducted with adjustment by CTO in a non-IRA, age, anemia (hemoglobin < 11 g/dL), CKD (eGFR ≤ 60 mL/min/1.73 m²), previous history of stroke and Killip classification. Diabetes mellitus was added as adjusted covariate in the model for 1-year MACE. CKD was defined as estimated GFR (eGFR) ≤ 60 mL/min/1.73 m². MACE: major adverse cardiac event. Other abbreviations as in Table 1, Table 2.