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. 2021 Mar 4;11:3719. doi: 10.1038/s41598-021-83239-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(a) A comparison of the inheritance scenarios of a homing-only gene drive (top row) and a homing-cleave-and-rescue gene drive (bottom row). The two panels in the left column show inheritance when homing is successful, and the two panels on the right show inheritance when homing fails. Each panel shows two parent squirrels and two offspring, each with the loci relevant for the gene drive. A legend for the gene drive components is provided. Squirrels colour coded halos represent their genotype: yellow = wildtype, turquoise = gene drive, blue = resistant, and purple = non-viable. (b) A potential HD-ClvR construct for grey squirrel. Colour coding is consistent with (a) and additionally, gRNAs are shown in grey. The gRNAs shown in this figure constitute one daisy element, multiple of these would constitute a daisyfield.