Figure 3.

Population size over time after the introduction of gene drive squirrels with either a standard homing, a standard cleave-and-rescue, or a homing-cleave-and-rescue gene drive to a population with carrying capacity 3000. All simulations are based on a single release of 100 squirrels is done, other than the standard cleave-and-rescue gene drive, which requires a release of 1000 squirrels. Lines represent the average population size over 100 model replications, while opaque ribbons represent the 95% quantiles. The model was run with 3 different rates of NHEJ repair during homing ($P_n$) and with different numbers of gRNAs for the homing and the cleave-and-rescue components of the gene drive.