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A molecular summary of APC germline mutations in the FAP-hESC lines. (A) Description of the type and location of APC germline mutations in each of the three FAP-hESC lines derived following preimplantation genetic diagnosis (PGD). (B) Schematic structure of the APC protein. Positions of the APC germline mutations in FAP1, FAP2 and FAP3-hESC lines are indicated by arrows. O-oligomerization domain, MCR- mutation cluster region, basic microtubule binding site.
