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. 2021 Mar 4;11:5113. doi: 10.1038/s41598-021-84564-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptome of FAP-hESC lines at different stages of differentiation into colon organoids. (A) Heat map of differentially expressed genes (DEGs) during differentiation of FAP-hESCs into colon organoids. Columns represent samples and rows represent genes, categorized in relation to pluripotency and to cell lineage (endoderm, ectoderm, and mesoderm). The heat map illustrates lower (blue) to high (red) gene expression levels with distinct transcriptional profiles across the differentiation process. (B) The volcano plots of DEGs in all three FAP-hESC lines compared to WT, on day 8 of differentiation into colon organoids. (C) Gene ontology biological process analysis of upregulated DEGs in FAP compared to WT cells, on day 8 of colon organoid differentiation. (D) Venn diagram showing the overlap of biological processes at day 8 of differentiation in FAP and WT cells.