Table 2.

Exploratory phase biomarkers (courtesy of Prof. L. Rodriguez Mañas)

Genomics and transcriptomics	Sistemas Genómicos	Genotyping of 256 polymorphism in candidate genes SNPs Expression study of candidate genes: IL4, IL7, IL17A, FASLG, MTOR, BCL2L1, FAS, OAZ1_HK, PMAIP1, IL10, NFE2L2, IL6, IFNG, TGFB1, PPARGC1A, TP53, PPARD, B2M_HK
	LifeLength	Telomere length
	Evercyte	96 Circulating miRNA (Aging/Senescence/Inflammaging/Longevity, Bone metabolism, musculoskeletal function, and fracture risk, Cardiovascular Disease)
	Sermas	Expression studies target genes for hypoxia inducible factors-HIF and ACE2, ARG2, CXCL10, EGLN3, EPAS1, MAS1, HMOX2, HIF1A, HIF3A, IL10, IL6, KDR, NOS2, NFE2L2, PTGS2, SOD2, SIRT1, CXCL12, TXNRD1, CYP27B1, VDR
Proteomics	Innsbruck	Serum concentration of secreted proteins from senescent endothelial cells. JAG1, IGFBP6, VERSICAN
	Cardiff	Plasma levels of glycated proteins, its soluble receptor and cognitive performance BM. CCL11, RAGE
	Sermas	Serum levels of HIF
	DIFE	Oxidized proteins: Protein.carbonyls, 3-Nitrotyrosine
	Mosaiques	Urinary proteome analysis
Metabolomics	U. Valencia	Metabolites: FFAA-CH2 & n.alloisoleucine.2, hydroxyvalerate & threonine & lactate, lysine/valine, CH2-isoleucine and CH-CH2-CH2
Classical non-omics biomarkers	Parma	Determination of traditional BM related to frailty: SuPAR, Pro.BNP, Troponin T, VCAM.1, ICAM-1, MMP-9, MMP-11, ACTIVIN-A, ADIPONECTIN, MYOSTATIN, GALECTIN-3, PCT, ESTRADIOL, A.N.A
	U. Valencia	BM of lypoperoxidation MDA, Polypeptides in urine
	DIFE	Fat-soluble micronutrients, 25 Hydroxyvitamin D D3 and D2 separately), Sum_lutein_zeaxanthin Beta, alpha_carotene, Retinol, protein_carbonyls, 3-Nitrotyrosine, Tocopherol, -Tocopherol, -Cryptoxanthin, Lycopene, Lutein/Zeaxanthin