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. 2021 Mar 4;11:5265. doi: 10.1038/s41598-021-83894-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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In situ adhesion assays were performed using fluorescently labelled MSCs or monocytes (Mo) added to TNF-α-activated monolayers of hPMVECs. Pre-activation of MSCs with TNF-α or LPS enhanced MSC adhesion ability (A,B). Treatment of U937 monocytes with conditioned media from Naïve MSCs allowed for greater adhesion, however conditioned media from MSCs pre-treated with inflammatory cytokines did not enhance this effect (C,D). MSC: Mesenchymal Stem Cell; TNF-α: Tumour Necrosis Factor α; hPMVEC: human pulmonary microvascular endothelial cells; LPS: Lipopolysaccharide; Mo: Monocyte; CM: Conditioned Media. Columns represent mean + SD (n = 6), * = P < 0.05 versus Control.