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. 2021 Mar 4;11:5265. doi: 10.1038/s41598-021-83894-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Administration of CFSE-labelled MSCs to murine models of E. coli pneumonia demonstrated that their therapeutic abilities were retained. Bacterial CFU were significantly reduced in BAL and lung tissue (A,B), total white cells counts and the fraction of inflammatory cells in the BAL were significantly reduced (C,D) and administration of MSCs resulted in a trend toward improved oxygenation (E,F).CFSE: Carboxyfluorescein succinimidyl ester; MSC: Mesenchymal Stem Cell; BAL: Bronchioalveolar lavage; CFU: Colony forming units. Columns represent mean + SD (n = 3–6),* = P < 0.05 versus Vehicle Control.