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. 2021 Mar 4;11:5244. doi: 10.1038/s41598-021-84881-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Correlations between serum SCFA levels in patients with CIS/MS and CD4⁺ T cell subsets. Top panel shows T regulatory cells (Treg; CD4⁺Foxp3⁺CXCR5⁻; n = 25), middle panel shows T follicular helper cells (Tfh; CD4⁺CXCR5⁺; n = 23), bottom panel shows T follicular regulatory cells (Tfr; CD4⁺Foxp3⁺CXCR5 + ; n = 25), and their correlation with (a,d,g) butyrate, (b,e,h) acetate and (c,f,i) propionate levels in serum. Statistical comparisons were made with nonparametric Spearman’s correlation; rho values and p values are shown. Linear regression line is shown for illustrative purposes only. Statistically significant p values are shown in bolded font.