Table 1.
Clinical and histological patients feature.
| Factor | Patients | |
|---|---|---|
| Pediatric | Adult | |
| Age (years) median (min.–max.) | 11.5 (4–17) | 50 (28–72) |
| Gender [male, %(n/total)] | 65.38 (17/26) | 52.94 (18/34) |
| Clinical and serological characteristics | ||
| BMI | ||
| Overweighed %(n/total) | 11.53 (3/26) | 29.41 (24/34) |
| Obese %(n/total) | 76.96(20/26) | 70.59 (10/34) |
| Transaminases | ||
| ALT (IU/l) median (min.–max.) | 31.5 (16–216) | 80 (31–279) |
| Elevated %(n/total) | 50 (13/26) | 94.12 (32/34) |
| AST (IU/l) median (min.–max.) | 40.5 (15–213) | 48 (22–208) |
| Elevated %(n/total) | 42.31 (11/26) | 61.76 (21/34) |
| AST/ALT ratio median (min.–max.) | 0.75(0.385–1.409) | 0.63 (0.32–1.07) |
| Lipid profile median (min.–max.) | ||
| Cholesterol mg/dl | 154.5 (88–224) | 207 (126–327) |
| Triglycerides mg/dl | 100 (28–212) | 166 (60–465) |
| Histological characteristics* | ||
| Steatosis%(n/total) | ||
| 0 | – | – |
| 1 | 15.38 (4/26) | 17.65 (6/34) |
| 2 | 19.23 (5/26) | 26.47 (9/34) |
| 3 | 65.39 (17/26) | 55.88 (19/34) |
| Lobular inflammation%(n/total) | ||
| 0 | 3.85 (1/26) | 17.65 (6/34) |
| 1 | 80.77 (21/26) | 64.70 (22/34) |
| 2 | 7.69 (2/26) | 17.65 (6/34) |
| 3 | 7.69 (2/26) | – |
| Ballooning %(n/total) | ||
| 0 | – | 11.76 (4/34) |
| 1 | 69.23 (18/26) | 64.71 (22/34) |
| 2 | 30.77 (8/26) | 23.53 (8/34) |
| NAFLD activity score %(n/total) | ||
| ≤ 2 | – | 8.82 (3/34) |
| 3–4 | 23.08 (6/26) | 38.24 (13/34) |
| ≥ 5 | 76.92 (20/26) | 52.94 (18/34) |
| Fibrosis %(n/total) | ||
| 0 | – | 67.65 (23/34) |
| 1 | 15.38 (4/26) | 14.71 (5/34) |
| 2 | 23.08 (6/26) | 11.76 (4/34) |
| 3 | 57.69 (15/26) | 5.88 (2/34) |
| 4 | 3.85 (1/26) | – |
| n | 26 | 34 |
BMI: Body Mass Index (kg/m2), in pediatric patients the values defined by the Argentine Society of Pediatrics were used to determine overweight and obesity (https://www.sap.org.ar/uploads/consensos/obesidad-gu-iacuteas-para-su-abordaje-cl-iacutenico-2015.pdf). In the case of adult patients: normal weight (< 25.0 kg/m2), overweight (25.0–29.9 kg/m2) and obesity (≥ 30 kg/m2). ALT alanine aminotransferase; AST aspartate aminotransferase. Normal ALT and AST levels for pediatric patients were ≤ 32 and ≤ 48 IU/L, respectively when testing was done at 37 °C. Normal ALT and AST levels for adult patients were ≤ 40 and ≤ 42 IU/L, respectively when testing was done at 37 °C. The normal ranges for cholesterol and triglyceride were 120–219 mg/dl and 31–119 mg/dl, respectively. *Steatosis Grade: score 0 (< 5%cells), 1 (5–33%), 2 (33–66%) and 3 (> 66%); lobular inflammation: score 0 (0 foci), 1 (< 2 foci), 2 (2–4 foci) and 3 (> 4 foci); ballooning grade: score 0 (none), 1 (few ballooning cells) and 2 (many cells/prominent cells); fibrosis stage: score 1 (a, b = mild (1a)/ moderate (1b) zone 3 perisinusoidal fibrosis; 1c = only portal fibrosis); 2 (zone 3 and portal/ periportal fibrosis), 3 (bridging fibrosis) and 4 (cirrhosis).