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. 2021 Mar 4;12:1446. doi: 10.1038/s41467-021-21574-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a PC1 by PC3 display of ATAC-seq data showing the distribution of iNKT cell subsets from different tissues. Liver = liv. b Heat map of relative RNA expression of selected AP-1 and ATF family genes in iNKT subsets from the indicated sites. c chromVAR computed deviation in ATAC-seq signal (Z-score) at regions containing indicated transcription factor motifs. Motifs with a p value less than 1e-25 are shown and families and representative members are labeled. Samples are indicated at the bottom, iNKT cell subsets from the lung are boxed to highlight lung-enriched motifs. d Total CTLA-4 expression in permeabilized iNKT cells from the indicated tissues. Representative cytogram of total iNKT cells (left) and percent CTLA-4⁺ cells within each subset from the different organs (right). Symbols depict individual mice, bars depict mean and SD. Data are combined from five experiments, n = 8 mice, statistical significance (p < 0.001 for NKT1 and p = 0.0004 for NKT2 and NKT17) assessed via Kruskal–Wallis tests. e CTLA-4 expression in permeabilized total iNKT cells from indicated tissues. Symbols depict individual mice, bars depict mean and SD, n = 8 mice from two independent experiments. Statistical significance (p < 0.0001) assessed via one-way ANOVA.