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. 2021 Mar 4;11:5241. doi: 10.1038/s41598-021-84812-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Light sheet analysis of ventricular wall dilation and infarct size. (a) Schematic illustration of apical conicity index calculation in Sham—vehicle heart. The index represents the ratio between the fitted triangle and striped area. (b) Same as above but shown for LAD—vehicle heart. Left ventricle (LV) wall dilation leads to increased area outside the fitted triangle. (c) Statistical comparison of cardiac conicity index. (d) Ejection fraction (EF) at week 4 shows negative correlation to conicity index (r = -0.76; p < 0.0001). (e) Representative example of light sheet imaged heart with infarct zone separated by line. (f) Segmented volume of cardiac wall with thickness below 400 µm (from sample shown in E). (g) Quantification of infarcted LV wall volume with thickness below 400 µm. Significance: *p < 0.05, **p < 0.01, ***p < 0.001. Scale bars: 1 mm. LAD: left anterior descending artery ligation.