Table 4.

Estimates of linear mixed effects models predicting change in AD markers by sex and prediabetes status in MCI subsample.

	Sex			Prediabetic status			Time			Sex X prediabetes			Prediabetes X time			Sex X time			Sex X prediabetes X time
	b	S.E.	p	b	S.E.	p	b	S.E.	p	b	S.E.	p	b	S.E.	p	b	S.E.	p	b	S.E.	p
AD biomarker
HV/IV	−0.39	0.11	<0.001	−0.20	0.13	0.13	−0.01	0.0009	<0.001	0.19	0.17	0.26	−0.002	0.001	0.07	0.003	0.001	0.003	0.0002	0.002	0.94
CMRglu	−0.04	0.02	0.04	−0.06	0.02	0.004	−0.002	0.0003	<0.001	0.07	0.03	0.02	0.0002	0.0004	0.68	0.0001	0.0004	0.78	0.0006	0.0008	0.45
p-tau/ Aβ ratio	−0.002	0.003	0.54	0.0009	0.003	0.80	0.0001	0.00004	<0.001	0.01	0.007	0.08	0.0001	0.0001	0.23	−0.00001	0.0001	0.46	−0.0002	0.0002	0.26
AD cognitive markers
AVLT Z score	−0.07	0.08	0.41	0.006	0.08	0.94	−0.004	0.001	<0.001	−0.02	0.16	0.90	−0.003	0.002	0.14	0.003	0.002	0.11	0.003	0.004	0.40
TMT Part B Z score	−0.57	0.28	0.04	−0.69	0.34	0.04	−0.02	0.005	<0.001	1.07	0.46	0.02	−0.009	0.01	0.23	0.002	0.01	0.77	0.002	0.01	0.89
BNT Z score	−0.35	0.43	0.41	−1.58	0.53	0.004	−0.03	0.01	0.006	1.45	0.71	0.04	−0.004	0.01	0.75	0.007	0.01	0.60	0.002	0.03	0.94

Bolded values indicate statistical significance. All analyses included the following covariates: age, education, race, APOE4 status, body mass index, pulse pressure, and history of cardiovascular events. Covariates were removed from the final model if not a significant predictor of the outcome. MCI, Mild Cognitive Impairment; HV/IV, hippocampal/intracranial volume × 10³. CMRglu, cerebral metabolic glucose rate; AVLT, Rey Auditory Verbal Learning Test; TMT, Trail Making Test; BNT, Boston Naming Test.