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. 2021 Feb 19;13:634412. doi: 10.3389/fnsyn.2021.634412

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Copyright © 2021 Geisler, Benedetti, Schöpf, Schwarzer, Stefanova, Schwartz and Obermair.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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General histologic examination of Nissl-stained brain sections does not reveal major morphological abnormalities. Representative micrographs of Nissl-stained sagittal cryosections obtained from adult (8–13-weeks-old; A,B) and juvenile (3–4-weeks-old; C,D) mouse brains. The cerebellum and hippocampus of ducky (A), α₂δ-1/-3 (B), α₂δ-1/-2 (C), α₂δ-2/-3 (D) double knockout mice showed no overt anatomical defects compared to control mice. Scale bars, 400 μm (Cerebellum), and 200 μm (Hippocampus).