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. 2021 Feb 19;8:619133. doi: 10.3389/fmed.2021.619133

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Copyright © 2021 Chen, Lin, Liu, Chai, Yeh, Hsu, Wu and Dai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The design of animal study. In the early treatment protocol, there were sham-operated rats, SU5416 combined with left pneumonectomy rats (SuPNx₄₂), and SuPNx₄₂ rats given with 15 mg DIZE/kg/day from day 1 to day 42 (SuPNx₄₂/DIZE₁₋₄₂). In the late treatment protocol, there were sham-operated rats (sham42), SuPNx₄₂, and a SuPNx₄₂ rats given with 15 mg DIZE/kg/day from day 29 to day 42 (SuPNx₄₂/DIZE₂₉₋₄₂). SuPNx, Su5416 with left pneumonectomy; DIZE, diminazene aceturate.