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. 2021 Feb 19;8:619133. doi: 10.3389/fmed.2021.619133

Figure 2.

Figure 2

Comparison of (A) right ventricle systolic pressure (RVSP), (B) Fulton index, the weight ratio of right ventricle to left ventricle plus septum (RV/LV+S), (C) the lung weight and (D) the body weight among the sham42, SuPNx42, SuPNx42/DIZE1−42 and SuPNx42/DIZE29−42 groups. RVSP levels were significantly higher in the SuPNx42 group (45.17 ± 4.62 mmHg) than in sham-operated rats (18.37 ± 1.36 mmHg, p < 0.001). Both DIZE treatment groups (SuPNx42/DIZE1−42 and SuPNx42/DIZE29−42) showed significant decreases in RVSP when compared with that of the SuPNx42 rats (early, 25.10 ± 1.38 mmHg, p < 0.01; late 31.23 ± 4.06 mmHg, p < 0.05). The Fulton index was significantly increased in the SuPNx42 group (0.55 ± 0.06) than in sham-operated group (0.35 ± 0.04, p < 0.05), but no significant changes were observed in the SuPNx42/DIZE1−42 and SuPNx42/DIZE29−42 groups when compared with the SuPNx42 group. There was no significant change in either the lung or body weight in all groups. Values represent the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 (n = 6–7).