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. 2021 Feb 19;12:627126. doi: 10.3389/fphar.2021.627126

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Copyright © 2021 Wang, Zhang, Yang, Chen, Zhuge, Xiong, Yang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Time-dependent analysis in liver injury and plasma coagulation index levels in rats. Sprague-Dawley rats were orally administered TA at a dose of 120 mg/kg. The rats were euthanized at 0.04, 0.13, 0.5, 1, 2, and 7 days after the administration, and the blood was then collected for analysis. (A), Representative image of hematoxylin and eosin staining of livers (10×). Scale bar, 50 μm. (B), PPAs contents in serum. (C), Serum ALT and AST activities. (D), PT, FIB, and TT levels. (E), Expression levels of miR-148a-3p, miR-362-5p, and miR-194-5p. Data were analyzed by one-way ANOVA and expressed as mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 vs. CTRL group.