TABLE 2.
Correlation analysis between the levels of three miRNA biomarkers and PPAs with related indexes in clinical laboratory.
| Correlation coefficient | hsa-miR-148a-3p | hsa-miR-362-5p | hsa-miR-194-5p | PPAs |
|---|---|---|---|---|
| Liver function indexes | ||||
| ALT | 0.768** | 0.689** | 0.626** | 0.609* |
| AST | 0.775** | 0.801** | 0.688** | 0.529* |
| ALP | 0.453* | 0.586** | 0.465* | 0.074 |
| GGT | 0.646** | 0.615** | 0.674** | 0.276 |
| TBIL | 0.429* | 0.662** | 0.518** | −0.219 |
| DBIL | 0.416* | 0.684** | 0.564** | −0.212 |
| Coagulation parameters | ||||
| PT | 0.474* | 0.520** | 0.171 | 0.222 |
| INR | 0.686** | 0.734** | 0.503* | 0.337 |
| TT | 0.508* | 0.596** | 0.555** | 0.072 |
| FIB | −0.587** | −0.657** | −0.526** | −0.101 |
| D-dimer | 0.804** | 0.709** | 0.501* | 0.288 |
ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; DBIL, direct bilirubin; FIB, plasma fibrinogen; GGT, λ-glutamyl transferase; INR, international normalized ratio; PPAs, pyrrole-protein adducts; PT, prothrombin time; TBIL, total bilirubin; TT, thrombin time. The correlation analyses were performed by the Spearman correlation method. *p < 0.05, **p < 0.01, ***p < 0.001.