TABLE 3.

Correlations between three miRNA biomarkers and PPAs with liver function indexes and coagulation parameters in rats treated with TA of G. japonica.

Correlation coefficient	rno-miR-148a-3p	rno-miR-362-5p	rno-miR-194-5p	PPAs
Liver function indexes
ALT	0.623**	0.704**	0.726**	0.729**
AST	0.652**	0.673**	0.718**	0.729**
Coagulation parameters
PT	0.846**	0.839**	0.854**	0.500
FIB	−0.717**	−0.797**	−0.738**	0.250
TT	0.746**	0.646*	0.746**	0.333
Other
PPAs	0.796*	0.475	0.893*	—

Rats were orally treated with TA of G. japonica and sacrificed at 1, 2 and 7 days after treatment. ALT, alanine aminotransferase; AST, aspartate aminotransferase; FIB, plasma fibrinogen; PPAs, pyrrole-protein adducts; PT, prothrombin time; TA, total alkaloids extract of G. japonica; TT, thrombin time. The correlation analyses were performed by the Spearman correlation method. *p < 0.05, **p < 0.01, ***p < 0.001.