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. 2021 Feb 19;12:641917. doi: 10.3389/fphar.2021.641917

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Copyright © 2021 Zhang, Wang, Qu, Chen, Wang, Li, Liu, Xu, Yoshida, Xu, Xie and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathological and biochemical assessment of liver injury. (A–C) Compared to the control group, METH-induced serious hepatocyte ballooning. Luteolin + METH group alleviated liver injury in comparison to the METH group. (D, E) METH significantly enhanced the level of ALT and AST in plasma relative to the control group. The increasing level was attenuated in the Luteolin + METH group.**p < 0.01, compared with control group, ^## p < 0.01, compared with METH group (mean ± SEM). Principal correlation analysis and correlation analysis among groups. (F) According to the principal component, intra-group samples were clustered respectively, and then, three groups were separated distinctly. L_M, luteolin + METH. (G) Correlation analysis among samples. The tree presents the correlation among samples, whereas the color displays the coefficient of correlation.