TABLE 7.
Representative examples of solid dispersion formulations.
| Technology | Drug molecule | BCS class | Trade name | Formulation | Therapeutic use |
|---|---|---|---|---|---|
| Nanocrystal (wet media milling) | Rapamycin | II | Rapamune | Tablets | Immuno-suppressant |
| Aprepitant | IV | Emend | Capsules | Antiemetic | |
| Fenofibrate | II | Tricor | Tablets | Antilipidemic | |
| Megestrol acetate | II | Megace ES | Oral suspension | Hormonal therapy | |
| High-pressure homogenization | Fenofibrate | II | Triglide | Tablets | Antilipidemic |
| Melt extrusion | Verapamil HCL | I | Isoptin SRE | Tablets | Antihypertensive |
| Nifedipine | II | Adalat SL | Capsules | Antihypertensive | |
| Troglitazone | II | Rezulin | Tablets | Antidiabetic | |
| Melt adsorption | Nifedipine | II | Afeditab | Tablets | Antihypertensive |
| Melt granulation (MeltDose® technology) | Fenofibrate | II | Fenoglide | Tablets | Antilipidemic |
| Tacrolimus | II | LCP-Tacro | Tablets | Immuno-suppressant | |
| Spray drying | Intelence | IV | Etravirine | Tablets | Antiviral |
| Itraconazole | II | Sporanox | Capsules | Antifungal | |
| Nilvadipine | II | Nivadil | Capsules | Antihypertensive | |
| Tacrolimus | II | Prograf | Capsules | Immuno-suppressant | |
| Lyophilization | Olanzapine | II | Zyprexa | Tablets | Antipsychotic |
| Ondansetron | II | Zofran ODT | Tablets | Antiemetic | |
| Piroxicam | II | Proxalyoc | Tablets | Anti-inflammatory |