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. 2021 Feb 19;11:622950. doi: 10.3389/fendo.2020.622950

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Copyright © 2021 Li, Lu, Xie, Chen, Tian, Liang, Li, Zhang, Liu and Yu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IL-6 KO attenuated senescence of BMCs in HFD-induced bone loss. (A) Representative images for colony formation of bone marrow cells (BMCs) from WT and IL-6 KO mice after SD or HFD treatment. The number of colonies per well was counted and calculated (right panel). (B) The mRNA levels of typical aging markers (p53, p21, p16) in BMCs from WT and IL-6 KO mice after SD or HFD. (C) Western blot analysis of indicated proteins (p53, p21, p-STAT3, STAT3, β-actin) in BMCs of WT and IL-6 KO mice fed with SD or HFD for 12 weeks. The expression of p53 and p21 was normalized against β-actin, and the expression of p-STAT3 was normalized against STAT3. Quantitative analysis with Image J software was shown on the right panel. Data were expressed as mean ± SD.