FIGURE 1.

Common differential expressed gene signatures in lung autopsies from five COVID-19 patients. (A) RNAseq data set containing expression profile from autopsy samples (Formalin-fixed paraffin-embedded lung tissues) from five patients deceased due to SARS-Cov2 infection, were analyzed. Each patient sample had three or more replicates. Mean expression was calculated and Log2 fold change was computed for each patient sample. Common differentially expressed genes were identified with a threshold of a Log2FC of 1.5 or above. Non-coding genes or pseudogenes were excluded. Total 101 genes were selected based on these criteria and the Venn diagram was constructed to represent the common genes. (B) Database containing 81 RNAseq samples derived from 12 Healthy lung donor subjects was utilized to identify selectivity of these commonly expression 101 genes. Most of the genes were non-selectively expressed. (C) Bar graph showing expression of those 101 genes in COVID-19 lung tissue compared to normal lung. All the values are representing Log2FC ± SEM for the relative mRNA expression in five COVID-19 cases compared vs. healthy controls.