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. 2021 Feb 19;10:610513. doi: 10.3389/fonc.2020.610513

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Copyright © 2021 Gao, Huang, Wang, Pan, Yin, Zhou and Zheng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional characteristics of four immune subclasses. (A) Heatmap of GSVA scores for indicated functional signatures. Color scale: GSVA score from −1 (blue) to +1(red). (B) Boxplot plot of the expression levels for selected immune-related pathways. (One-way ANOVA test). Boxplot of the expression (C) and methylation (D) levels of immune checkpoint-related genes between C2 and non-C2 subclass. (Student’s t test). All P values labels: ns P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001). Error bars are presented as the standard deviation (SD).