FIGURE 1.

Structure of MazF-dr. (A) Structure-based sequence alignment of MazF proteins. MazF proteins from D. radiodurans, B. subtilis, E. coli, and S. aureus are denoted as dr_mazF, bs_mazF, ec_mazF, and sa_mazF, respectively. Residues conserved within MazF proteins are colored white. Two catalytic residues, namely, Arg29 and Thr52, are highlighted in red. (B) Structure of the MazF-dr protomer. Secondary structures, the β1–β2 loop and N- and C-termini are colored and labeled. Two catalytic residues, namely, Arg29 and Thr52, are shown as sticks and highlighted in magenta. (C) The MazF-dr dimer is shown as a cartoon, and the two protomers are colored green and yellow. Structural elements including the β1–β2 loop located at the dimer interface are labeled.