Table 3.

Cox Proportional Hazard Analysis for All-Cause Mortality

	Univariable			Multivariable
	HR	95% CI	P value	HR	95% CI	P value
Age	1.03	0.99–1.07	0.20
Female sex	0.43	0.28–0.64	<0.001	0.51	0.34–0.79	0.002
BMI	1.86	0.57–6.04	0.30
NYHA III or IV	1.81	1.19–2.74	0.005	1.18	0.73–1.91	0.50
Hypertension	0.69	0.44–1.08	0.10
Diabetes	1.23	0.78–1.95	0.38
Peripheral artery disease	1.60	0.99–2.58	0.055
Stroke	1.90	1.12–3.21	0.017	1.71	0.97–3.03	0.065
AF/AFL	2.42	1.60–3.65	<0.001	2.30	1.48–3.58	<0.001
COPD	2.33	1.12–4.82	0.023	2.01	0.87–4.63	0.10
OMI	1.13	0.52–2.45	0.75
eGFR	0.99	0.98–1.00	0.16
Hemoglobin	0.89	0.77–1.03	0.11
Albumin	0.26	0.16–0.40	<0.001	0.30	0.19–0.49	<0.001
Aortic valve area	0.62	0.16–2.44	0.49
MR ≥ moderate	1.74	0.64–4.75	0.28
General anesthesia	1.50	0.92–2.48	0.10
Transfemoral approach	0.67	0.40–1.13	0.14
Device success	0.38	0.18–0.78	0.009	0.49	0.20–1.20	0.12
Procedural stroke	1.09	0.35–3.46	0.88
Life-threatening bleeding	2.19	0.89–5.42	0.090
Acute kidney injury Stage 2 or 3	3.54	1.30–9.68	0.014	1.52	0.49–4.70	0.47
Major vascular complication	0.87	0.28–2.75	0.81
Pacemaker implantation	1.15	0.53–2.22	0.68
AR ≥ moderate	3.60	1.30–9.97	0.014	1.42	0.37–5.52	0.61
Non-home vs. home discharge	3.11	1.79–5.43	<0.001	1.54	0.82–2.91	0.18

HR, hazard ratio. Other abbreviations as in Tables 1,2.