Figure 6.

Correlation of transcriptional expression between genes in the ICN and clinically actionable genes (CAGs)

Pearson’s correlation coefficients |R| > 0.3, p < 0.05; blue indicates a negative correlation; red indicates a positive correlation; color scale reflects Pearson’s correlation coefficient. The x axis (CAGs) is ordered by the number of positively correlated genes in the ICN minus the number of negatively correlated genes in the ICN. The y axis (genes in the ICN) is ordered by the total number of correlated CAGs. If the number of cancer types is less than five, the fill color of the cell is white. Bold boxes highlight the transcriptional factor-gene interactions of CAGs and genes in the ICN. × marks the protein-protein interactions (PPIs) of CAGs and genes in the ICN based on the experimental evidence from HPRD.