Figure 7.

Clinical relevance of the ICN across 21 kinds of cancer.

(A) Clinical relevance of the ICN across different cancer types. Pink boxes indicate genes that are differently expressed between the ICN and different cancer samples. Dark yellow and light yellow boxes represent the upregulation or downregulation of genes in later stages (fold change of transcriptional expression between stages III/IV and stages I/II larger than 1.5). Dark green and light green boxes indicate high and low expression in tumors associated with worse overall survival times (log-rank test FDR < 0.05), respectively. (B) Kaplan-Meier curves of multiple cancer types stratified by median expression level of E2F2 and ITGB8.