Figure 4.
IL-18 effects on Ito in murine SCD hearts. (A) KCND2 and KCND3 gene expression levels were lower in SCD mice compared with CTR mice (n = 5 mice for both groups). (B) Representative Ito traces from CTR and SCD myocytes. (C) Current-voltage curve of Ito shows that the SCD heart has lower Ito amplitude above 0 mV, which is further reduced by IL-18 (25 ng/mL) (n = 5 mice for CTR group; n = 6 mice for SCD group). *P < .05; **P < .01 compared with CTR group. †P < .05, compared with SCD group. Error bars in panels A and C represent standard error. nA, nanoampere; pA, picoampere; pF, picofarad.