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. 2021 Feb 24;21(4):326. doi: 10.3892/ol.2021.12588

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Copyright: © Yao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Effect of MET knockdown on PANC-1 cells. (A) Transfection efficiency of MET knockdown was assessed via reverse transcription-quantitative PCR analysis. (B) The results of the Cell Counting Kit-8 assay demonstrated that MET knockdown significantly inhibited the proliferation of PANC-1 cells. (C) The results of the wound healing assay demonstrated that MET knockdown significantly inhibited cell migration. Scale bar, 200 µm. (D) The results of the Transwell assay demonstrated that MET knockdown significantly inhibited cell invasion. Scale bar, 100 µm. (E) Western blot analysis demonstrated that MET knockdown inhibited phosphorylation of the PI3K/AKT pathway. *P<0.05, **P<0.01, ***P<0.001 vs. control group. si, small interfering; NC, negative control; ns, no significance; p, phosphorylated.