Table 1.
Demographics of all participants
| Columbia cohort |
HC (LRRK2−/PD−) (n = 35) |
NMC (LRRK2+/PD−) (n = 16) |
iPD (LRRK2−/PD+) (n = 40) |
LLRK2 PD (LRRK2+/PD+) (n = 28) |
|---|---|---|---|---|
| Age at collection, mean (SD) | 67.5 (10.3) | 56.8 (12.7) | 64.9 (9.2) | 70.7 (8.7) |
| Age at onset, mean (SD) | n/a | n/a | 57.8 (11) | 57.9 (11.3) |
| Sex (female/male) | 17/18 | 8/8 | 15/25 | 11/17 |
| GBA (mut/WT) | 7/28 | 1/15 | 11/29 | 3/25 |
| MoCA, mean (SD) | 27.5 (2) | 28.7 (1.1) | 26.9 (1.6) | 26.3 (4.5) |
| UPDRS‐III, mean (SD) | 1.1 (1.5) | 0.8 (1.1) | 17.7 (10) | 20.6 (8) |
| LCC cohort |
HC (LRRK2−/PD‐) (n = 26) |
NMC (LRRK2+/PD−) (n = 37) |
iPD (LRRK2−/PD+) (n = 29) |
LLRK2 PD (LRRK2+/PD+) (n = 23) |
|---|---|---|---|---|
| Age at collection, mean (SD) | 56.1 (16) | 52.1 (12.1) | 65 (9.1) | 68.4 (5) |
| Age at onset, mean (SD) | n/a | n/a | 58.4 (9.1) | 57.7 (7.6) |
| Sex (female/male) | 15/11 | 16/21 | 9/20 | 13/10 |