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. 2021 Jan 18;69(2):214–225. doi: 10.4103/ijo.IJO_1263_20

Table 7.

Differences between keratoglobus and keratoconus

Keratoglobus (KG) Keratoconus (KC)
Entire cornea is thinned out in KG Central and paracentral thinning occurs in KC
Bilateral, presents since birth Bilateral or Unilateral, presents at any age after birth usually in second or third decade
Non- Progressive disorder
No association with Down’s syndrome commonly
Progressive condition
KC is common in Down’s syndrome children (incidence is 5.5% - 15%)
Associated with autosomal recessive pattern of inheritance Usually isolated condition
Prone for rupture following trivial trauma Corneal rupture is uncommon in KC
Optical rehabilitation with glasses is usually indicated in KG Contact lens rehabilitation can be offered for visual rehabilitation in KC patients
Keratoplasty carries poor prognosis due to proximity of limbus. Recommended surgical techniques such as Tuck-in lamellar keratoplasty (TILK) are more demanding Keratoplasty and DALK procedures carry the good prognosis in advanced cases