FIGURE 4.

Crosstalk between exosome release and the autophagic process. Autophagy can regulate the release of exosomes. As shown in the figure, the amphisomes represent the intersection of exosome biogenesis and the autophagic process. Different autophagic‐related proteins (ATG5, ATG16L1 and LC3B) located on the membrane of MVBs, facilitate exosome biogenesis. Rab7 mediates the transport of MVBS to lysosomes. Rab11 promotes the fusion of MVB and autophagosomes into amphisomes. Rab11, Rab27 and Rab35 are involved in MVBs fusion with the PM to release exosomes. PM, plasma membrane; MVB, multiple vesicle bodies