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. 2021 Jan 20;13(3):e11900. doi: 10.15252/emmm.201911900

Figure 2. CamkIIδc TG mice display impaired hippocampus‐dependent memory function.

Figure 2

  1. The distance traveled (left panel), the speed (middle panel), and the time spent in the center region (right panel) during a 5‐min open field test was similar among 3‐month‐old CamkIIδc TG (n = 16) and control mice (n = 13). Unpaired t‐test, two‐tailed.
  2. The time to enter the escape hole during training sessions of the Barnes maze test is impaired in old CamkIIδc TG (n = 16) and control mice (n = 13; two‐way ANOVA, *P < 0.05).
  3. Plots showing the different search strategies of CamkIIδc TG (n = 16) and control mice (n = 13) across training trials. Each strategy is labeled with a unique color.
  4. The cumulative score of hippocampus‐dependent search strategies during Barnes maze training is impaired in CamkIIδc TG (n = 16) when compared to control mice (n = 13; two‐tailed, unpaired t‐test, *P < 0.05).
  5. Number of visits to escape hole during probe test to assay memory retrieval was impaired in CamkIIδc TG (n = 16) when compared to control mice (n = 13; two‐tailed, unpaired t‐test, *P < 0.05).

Data information: Bars and error bar indicates mean ± SEM.