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. 2021 Jan 24;25(5):2517–2529. doi: 10.1111/jcmm.16199

FIGURE 6.

FIGURE 6

LKB1IP positively regulates Akt phosphorylation. (A) Western blot analysis of phosphorylated Akt from hearts of ISO‐infused WT and LKB1IP‐/‐ mice (n = 4). *P < .05, **P < .01vs WT Saline; # P < .05 vs WT ISO. (B) Western blot analysis of phosphorylated Akt level in hearts of WT and LKB1IP‐/‐ mice after TAC surgery (n = 4). **P < .01, ***P < .001vs WT Sham; #### P < .0001 vs WT TAC. (C) Western blot analysis of phosphorylated Akt level in NRCMs infected with AdGFP or AdLKB1IP followed by ISO treatment (n = 3). ***P < .001 vs AdGFP Saline; ## P < .01 vs AdGFP ISO. (D) Western blot analysis of phosphorylated Akt level in NRCMs transfected with control or LKB1IP siRNA followed by ISO treatment (n = 3). **P < .01, ****P < .0001 vs Control siRNA Saline; ## P < .01 vs Control siRNA ISO