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. 2021 Mar 3;218(5):e20210281. doi: 10.1084/jem.20210281

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© 2021 Andreano and Rappuoli

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 1. — The cryptic role of IGHV3-53 and IGHV3-66 antibodies in COVID-19. Summary of the roles of two predominant antibody germlines elicited by COVID-19 infection. (A–C) The figure shows different functions of IGHV3-53 and IGHV3-66 antibodies after infection which are virus neutralization (A), evolution of escape variants (B), and possible autoimmunity (C).