Table 1.
Summary of clinical trials using mesenchymal stem cells against pneumonia till November 2020
| Categories |
Clinical trial ID |
Status |
Study description & target conditions |
Form/source of MSCs/derivatives |
Locations |
| MSCs | NCT04252118 | Recruiting | MSCs treatment for pneumonia patients infected with COVID-19 | MSCs | Beijing 302 Military Hospital of China, Beijing, China |
| NCT04288102 | Recruiting | Treatment with MSCs for COVID-19 | MSCs | Maternal and Child Hospital of Hubei Province, Wuhan, Hubei, China and Wuhan Huoshenshan Hospital, Wuhan, Hubei, China | |
| NCT04313322 | Recruiting | Treatment of COVID-19 patients using Wharton's jelly MSCs | Wharton's jelly MSCs | Stem Cells Arabia, Amman, Jordan | |
| NCT04366063 | Recruiting | MSCs therapy for SARS-CoV-2-related acute respiratory distress syndrome | MSCs | Royan Institute, Tehran, Iran, Islamic Republic | |
| NCT04392778 | Recruiting | Clinical use of stem cells for the treatment of COVID-19 | MSCs | Istinye University, Istanbul, TurkeySBÜ Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi, Istanbul, Turkey | |
| NCT04315987 | Not yet recruiting | NestCell® MSCs to treat patients with severe COVID-19 pneumonia | NestCell® | Hospital Vera Cruz, Campinas, São Paulo, BrazilHospital de Barueri, São Paulo, BrazilIncCOR, São Paulo, BrazilUNIFESP, São Paulo, Brazil | |
| NCT02013700 | Completed | Allogeneic human cells in patients with idiopathic pulmonary fibrosis via intravenous delivery | Allogeneic adult human MSCs | Interdisciplinary Stem Cell Institute / University of Miami, Miami, Florida, United States | |
| MSCs with drugs | NCT04371601 | Active,not recruiting | Safety and effectiveness of MSCs in the treatment of pneumonia of COVID-2019 | MSCs combined with drugs (oseltamivir/hormones)/oxygen therapy | Fuzhou General Hospital, Fuzhou, Fujian, China |
| Bone marrow-derived MSCs | NCT01919827 | Completed | Study of autologous MSCs to treat idiopathic pulmonary fibrosis | Autologous bone marrow-derived MSCs (adult) via endobronchial infusion | Servicio de Neumología, Clínica Universidad de Navarra, Pamplona, Navarra, Spain Servicio de Neumología. Hospital Universitario de Salamanaca, Pamplona, Navarra, Spain |
| NCT02594839 | Completed | Safety and efficacy of allogeneic MSCs in patients with rapidly progressive idiopathic interstitial pneumonia | Bone marrow-derived MSCs | Federal Research Clinical Center FMBA of Russia, Moscow, Russian Federation | |
| NCT04346368 | Recruiting | Bone marrow-derived MSCs treatment for severe patients with COVID-19 | Bone marrow-derived MSCs | Guangzhou Institute of Respiratory Health, Guangzhou Medical University, Guangzhou, Guangdong, China | |
| NCT04348435 | Recruiting | A clinical trial to determine the safety and efficacy of hope biosciences autologous MSCs therapy to provide protection against COVID-19 | Human umbilical cord derived CD362 enriched MSCs | Hope Biosciences Stem Cell Research Foundation, Sugar Land, Texas, United States | |
| Umbilical cord MSCs | NCT04269525 | Recruiting | Umbilical cord-derived MSCs treatment for the 2019-novel coronavirus pneumonia | Umbilical cord MSCs | Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China |
| NCT04273646 | Not yet recruiting | Study of human umbilical cord MSCs in the treatment of severe COVID-19 | Umbilical cord MSCs | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China | |
| NCT04282928 | Not yet recruiting | Safety and efficacy of umbilical cord MSCs for the treatment of severe viral pneumonia | Umbilical cord MSCs | Shanghai East Hospital, Shanghai, Shanghai, China | |
| NCT04339660 | Recruiting | Clinical research of human MSCs in the treatment of COVID-19 pneumonia | Umbilical cord MSCs | Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, China | |
| NCT04490486 | Not yet recruiting | Umbilical cord tissue derived MSCs vs placebo to treat acute pulmonary inflammation due to COVID-19 | Umbilical cord MSCs | University of Miami, Miami, Florida, United States | |
| NCT04398303 | Not yet recruiting | ACT-20 in patients with severe COVID-19 pneumonia | ACT-20-MSC | N/A | |
| Umbilical cord MSCs with drugs | NCT04457609 | Recruiting | Administration of allogenic umbilical cord-MSCs as adjuvant therapy for critically-Ш COVID-19 patients | Umbilical cord MSCs with drugs (oseltamivir/azithromycin ) | Cipto Mangunkusumo General Hospital, Jakarta Pusat, DKI Jakarta, IndonesiaPersahabatan General Hospital, Jakarta, DKI Jakarta, Indonesia Sulianti Saroso Center for Infectious Disease, Jakarta, DKI Jakarta, IndonesiaUniversitas Indonesia Hospital, Depok, West Java, Indonesia |
| Adipose MSCs | NCT04349631 | Enrolling by invitation | Adipose mesenchymal cells for abatement of SARS CoV-2 respiratory compromise in COVID-19 | Hope biosciences-adipose derived MSCs | Hope Biosciences Stem Cell Research Foundation, Texas, United States |
| NCT04352803 | Not yet recruiting | Adipose mesenchymal cells for abatement of SARS-CoV-2 respiratory compromise in COVID-19 | Autologous adipose MSCs | N/A | |
| NCT04366323 | Recruiting | Safety and efficacy of intravenous administration of allogeneic adult MSCs of expanded adipose tissue in patients with severe pneumonia due to COVID-19 | Allogeneic and expanded adipose tissue-derived MSCs | Hospital Universitario de Jerez de la Frontera, Jerez de la Frontera, Cádiz, Spain Hospital Reina Sofía, Córdoba, Spain Hospital Universitario Virgen de las Nieves, Granada, Spain Hospital Universitario Virgen Macarena, Sevilla, Spain Hospital Unversitario Virgen del Rocío, Sevilla, Spain Hospital Nuestra Señora de Valme, Sevilla, Spain | |
| MScs derived from other tissues | NCT04302519 | Not yet recruiting | Novel coronavirus induced severe pneumonia treated by dental pulp MSCs | Dental pulp MSCs | N/A |
| NCT04336254 | Recruiting | Safety and efficacy study of allogeneic human dental pulp MSCs to treat severe COVID-19 patients | Allogeneic human dental pulp stem cells | Renmin Hospital of Wuhan University (East Campus), Wuhan, Hubei, China | |
| NCT04382547 | Enrolling by invitation | Treatment of COVID-19 associated pneumonia with allogenic pooled olfactory mucosa-derived MSCs | Allogenic pooled olfactory mucosa-derived MSCs | Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus, Minsk, Belarus | |
| NCT01385644 | Completed | A study to evaluate the potential role of MSCs in the treatment of idiopathic pulmonary fibrosis | Placental MSCs | The Prince Charles Hospital, Brisbane, Queensland, Australia | |
| MSC-derived exosomes | NCT04276987 | Completed | A pilot clinical study on inhalation of mesenchymal stem cells exosomes treating severe COVID-19 induced pneumonia | MSC-derived exosomes | Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China |
| NCT04602442 | Enrolling by invitation | Safety and efficiency of method of exosome inhalation in COVID-19 associated pneumonia | MSC-derived exosomes | Medical Centre Dinasty, Samara, Russian Federation | |
| Others | NCT04299152 | Not yet recruiting | Stem cell educator therapy treat the viral inflammation in COVID-19 | Stem cell educator-treated mononuclear cells apheresis | N/A |
Information retrieved and reconstructed from the United States National Library of Medicine. MSC: Mesenchymal stem cell; COVID-19: Coronavirus disease 2019; SARS-CoV-2: Severe acute respiratory syndrome coronavirus-2; N/A：Not applicable.