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. 2021 Mar 4;4(3):e210689. doi: 10.1001/jamanetworkopen.2021.0689

Figure 2. Number of Registered Interventional Trials for Sepsis Treatments.

Figure 2.

A, Exponential growth in the number of trials of vitamin C registered in ClinicalTrials.gov occurred after the publication and promotion of a single-center retrospective cohort study using historical controls, in contrast to trials of corticosteroids and heparin, which showed slow linear increases. B, This exponential growth occurred in all trials with vitamin C, irrespective of whether vitamin C was combined with corticosteroids.