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. 2021 Feb 27;13(2):218–232. doi: 10.4254/wjh.v13.i2.218

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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Matrix metalloproteinase productions according to fibrosis stage. Serum concentrations of A: Matrix metalloproteinase (MMP)-2; B: MMP-7 and C: MMP-9 of chronic hepatitis C patients classified according to fibrosis grades F0, F1, F2, F3 and F4. Statistical differences of MMP-7 were observed in 1 = F0 vs F1^a; 2 = F0 vs F3^b; 3 = F0 vs F4^b; 4 = F1 vs F3^b; 5 = F1 vs F4^b; 6 = F2 vs F3^a, 7 = F3 vs F4^b. Data are expressed as mean ± standard error of the mean. ^aP < 0.05; ^bP < 0.01.