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. 2021 Feb 27;13:2515841421997191. doi: 10.1177/2515841421997191

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© The Author(s), 2021

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Architecture of the BEST1 channel. (a) The structure of a BEST1 protein unit is divided into four segments, composed of alpha helices represented as S1a-c (red), S2a-h (yellow), S3a-b (blue) and S4a-b (magenta), the transmembrane regions (TM) are indicated. The calcium clasp is represented by a turquoise sphere and the start of the C-terminal tail is coloured green. (b) The BEST1 channel, viewed from the extracellular side, is formed from five BEST1 proteins arranged in a pentameric structure, forming a barrel shaped ion pore (c).