Table 2. Results of Additional Cardiac Testing and Participation Status of Athletes With Abnormalities on Baseline Cardiac Screening Examinationsa.
Athlete No. | Symptomatic infection | COVID-19 test | Abnormal results | Echo abnormality | Additional testing | Participation statuse | |||
---|---|---|---|---|---|---|---|---|---|
Troponin levelb | ECGc | Echod | Cardiac MRI | Stress echo | |||||
1 | Yes | PCR | Yes | No | No | NA | Normal LVEF; no LGE; no CMR evidence of myocarditis | Normal LV augmentation with exercise; no exercise-induced arrhythmias | Return to play |
2 | Yes | PCR | Yes | No | No | NA | Normal LVEF; no LGE; no CMR evidence of myocarditis | Normal LV augmentation with exercise; no exercise-induced arrhythmias | Return to play |
3 | Yes | PCR | No | No | Yes | Small pericardial effusion | Normal LVEF; no LGE; no CMR evidence of myocarditis/pericarditis | NA | Return to play |
4 | Yes | PCR | No | No | Yes | Small pericardial effusion | CMR pericardial enhancement diagnostic of pericarditis; no LGE; no CMR evidence of myocarditis | NA | Held out |
5 | Yes | PCR | No | No | Yes | LVEF, 53% | NA | Normal LV augmentation with exercise; no exercise-induced arrhythmias | Return to play |
6 | No | IgG | No | No | Yes | LVEF, 53% | NA | Normal LV augmentation with exercise; no exercise-induced arrhythmias | Return to play |
7 | No | IgG | Yes | No | No | NA | Normal LVEF; no LGE; no CMR evidence of myocarditis | Normal LV augmentation with exercise; no exercise-induced arrhythmias | Return to play |
8 | No | IgG | No | No | Yes | Mildly reduced LVEF, 45%-50% | CMR-calculated LVEF, 53%; no LGE; no CMR evidence of myocarditis | Normal LV augmentation with exercise; no exercise-induced arrhythmias | Return to play |
9 | Yes | IgG | No | No | Yes | Mildly reduced LVEF, 45% | CMR-calculated LVEF, 56%; no LGE; no CMR evidence of myocarditis | NA | Return to play |
10 | No | IgG | Yes | No | No | NA | NA | Normal LV augmentation with exercise; no exercise-induced arrhythmias | Return to play |
11 | Yes | PCR | No | No | Yes | Mildly reduced LVEF, 48% | CMR-calculated LVEF, 53%; no LGE; no CMR evidence of myocarditis | NA | Return to play |
12 | Yes | PCR | Yes | No | Yes | Mildly reduced LVEF, 50% | CMR-calculated LVEF, 44%; patchy LGE present; CMR findings consistent with myocarditis | NA | Held out |
13 | Yes | PCR | No | Yes | No | NA | CMR-calculated LVEF, 78%; no LGE; no CMR evidence of myocarditis | Normal LV augmentation with exercise; no exercise-induced arrhythmias | Return to play |
14 | Yes | PCR | No | No | Yes | Mildly reduced LVEF, 45% | CMR-calculated LVEF, 52%; no LGE; no CMR evidence of myocarditis | Normal LV augmentation with exercise; no exercise-induced arrhythmias | Return to play |
15 | Yes | PCR | No | No | Yes | Small pericardial effusion | Normal LVEF; no LGE; no CMR evidence of myocarditis or pericarditis | NA | Return to play |
16 | No | IgG | No | Yes | No | NA | Normal LVEF; no LGE; no CMR evidence of myocarditis | NA | Return to play |
17 | Yes | PCR | No | Yes | Yes | Impaired LV relaxation | Normal LVEF; no LGE; no CMR evidence of myocarditis | NA | Return to play |
18 | No | IgG | No | No | Yes | Mild global LV hypokinesis | CMR-calculated LVEF, 46%; no LGE; no CMR evidence of myocarditis or pericarditis | Normal LV augmentation with exercise; no exercise-induced arrhythmias | Return to play |
19 | Yes | PCR | Yes | No | No | NA | CMR pericardial enhancement diagnostic of pericarditis; no LGE; no CMR evidence of myocarditis | NA | Held out |
20 | Yes | PCR | No | No | Yes | Mild global LV hypokinesis | No CMR evidence of myocarditis | Normal LV augmentation with exercise; no exercise-induced arrhythmias | Return to play |
21 | Yes | PCR | No | Yes | No | NA | No CMR evidence of myocarditis | NA | Return to play |
22 | No | IgG | No | No | Yes | Dilated right ventricle | No CMR evidence of myocarditis | NA | Return to play |
23 | Yes | PCR | No | Yes | No | NA | No CMR evidence of myocarditis | NA | Return to play |
24 | Yes | PCR | No | No | Yes | Frequent PVCs | No CMR evidence of myocarditis | Normal LV augmentation with exercise; no exercise-induced arrhythmias | Return to play |
25 | Yes | PCR | No | No | Yes | Decreased GLS | No CMR evidence of myocarditis | Normal LV augmentation with exercise; no exercise-induced arrhythmias | Return to play |
26 | Yes | PCR | No | Yes | No | NA | No CMR evidence of myocarditis | Normal LV augmentation with exercise; no exercise-induced arrhythmias | Return to play |
27 | Yes | PCR | No | Yes | Yes | Decreased GLS | No CMR evidence of myocarditis | Normal LV augmentation with exercise; no exercise-induced arrhythmias | Return to play |
28 | Yes | PCR | No | Yes | Yes | New regional wall motion abnormality in comparison with prior echocardiographic studies; preserved LVEF | Normal LVEF; LGE present in corresponding territory as echocardiogram; CMR findings consistent with myocarditis | NA | Held out |
29 | Yes | PCR | No | No | Yes | Dilated right ventricle | Normal LVEF and RV systolic function; focal T2 hyperintensity in the mid-ventricular inferior wall; CMR findings consistent with myocarditis | NA | Held out |
30 | Yes | PCR | No | Yes | No | NA | No CMR evidence of myocarditis | NA | Return to play |
Abbreviations: CMR, cardiac magnetic resonance imaging; COVID-19, coronavirus disease 2019; ECG, electrocardiogram; echo, echocardiogram; GLS, global longitudinal strain; LGE, late gadolinium enhancement; LV, left ventricle; LVEF, left ventricular ejection fraction; NA, not applicable; PCR, polymerase chain reaction; PVC, premature ventricular contractions.
There were 4 women and 26 men ranging in age from 19 to 35 years. Age and sex are not specified for each athlete in this table to maintain confidentiality.
Abnormal troponin levels were defined as those greater than the 99th percentile upper limit of normal.
An abnormal ECG was defined as a new ECG abnormality meeting international recommendations9 and demonstrating findings raising concern for potential acute cardiac injury.
An abnormal echocardiogram was defined as new ventricular dysfunction or another echocardiographic finding raising concern for potential acute cardiac injury.
Following American Heart Association/American College of Cardiology myocarditis or pericarditis guidelines.10