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. 2021 Mar 4;6(7):1–8. doi: 10.1001/jamacardio.2021.0565

Table 2. Results of Additional Cardiac Testing and Participation Status of Athletes With Abnormalities on Baseline Cardiac Screening Examinationsa.

Athlete No. Symptomatic infection COVID-19 test Abnormal results Echo abnormality Additional testing Participation statuse
Troponin levelb ECGc Echod Cardiac MRI Stress echo
1 Yes PCR Yes No No NA Normal LVEF; no LGE; no CMR evidence of myocarditis Normal LV augmentation with exercise; no exercise-induced arrhythmias Return to play
2 Yes PCR Yes No No NA Normal LVEF; no LGE; no CMR evidence of myocarditis Normal LV augmentation with exercise; no exercise-induced arrhythmias Return to play
3 Yes PCR No No Yes Small pericardial effusion Normal LVEF; no LGE; no CMR evidence of myocarditis/pericarditis NA Return to play
4 Yes PCR No No Yes Small pericardial effusion CMR pericardial enhancement diagnostic of pericarditis; no LGE; no CMR evidence of myocarditis NA Held out
5 Yes PCR No No Yes LVEF, 53% NA Normal LV augmentation with exercise; no exercise-induced arrhythmias Return to play
6 No IgG No No Yes LVEF, 53% NA Normal LV augmentation with exercise; no exercise-induced arrhythmias Return to play
7 No IgG Yes No No NA Normal LVEF; no LGE; no CMR evidence of myocarditis Normal LV augmentation with exercise; no exercise-induced arrhythmias Return to play
8 No IgG No No Yes Mildly reduced LVEF, 45%-50% CMR-calculated LVEF, 53%; no LGE; no CMR evidence of myocarditis Normal LV augmentation with exercise; no exercise-induced arrhythmias Return to play
9 Yes IgG No No Yes Mildly reduced LVEF, 45% CMR-calculated LVEF, 56%; no LGE; no CMR evidence of myocarditis NA Return to play
10 No IgG Yes No No NA NA Normal LV augmentation with exercise; no exercise-induced arrhythmias Return to play
11 Yes PCR No No Yes Mildly reduced LVEF, 48% CMR-calculated LVEF, 53%; no LGE; no CMR evidence of myocarditis NA Return to play
12 Yes PCR Yes No Yes Mildly reduced LVEF, 50% CMR-calculated LVEF, 44%; patchy LGE present; CMR findings consistent with myocarditis NA Held out
13 Yes PCR No Yes No NA CMR-calculated LVEF, 78%; no LGE; no CMR evidence of myocarditis Normal LV augmentation with exercise; no exercise-induced arrhythmias Return to play
14 Yes PCR No No Yes Mildly reduced LVEF, 45% CMR-calculated LVEF, 52%; no LGE; no CMR evidence of myocarditis Normal LV augmentation with exercise; no exercise-induced arrhythmias Return to play
15 Yes PCR No No Yes Small pericardial effusion Normal LVEF; no LGE; no CMR evidence of myocarditis or pericarditis NA Return to play
16 No IgG No Yes No NA Normal LVEF; no LGE; no CMR evidence of myocarditis NA Return to play
17 Yes PCR No Yes Yes Impaired LV relaxation Normal LVEF; no LGE; no CMR evidence of myocarditis NA Return to play
18 No IgG No No Yes Mild global LV hypokinesis CMR-calculated LVEF, 46%; no LGE; no CMR evidence of myocarditis or pericarditis Normal LV augmentation with exercise; no exercise-induced arrhythmias Return to play
19 Yes PCR Yes No No NA CMR pericardial enhancement diagnostic of pericarditis; no LGE; no CMR evidence of myocarditis NA Held out
20 Yes PCR No No Yes Mild global LV hypokinesis No CMR evidence of myocarditis Normal LV augmentation with exercise; no exercise-induced arrhythmias Return to play
21 Yes PCR No Yes No NA No CMR evidence of myocarditis NA Return to play
22 No IgG No No Yes Dilated right ventricle No CMR evidence of myocarditis NA Return to play
23 Yes PCR No Yes No NA No CMR evidence of myocarditis NA Return to play
24 Yes PCR No No Yes Frequent PVCs No CMR evidence of myocarditis Normal LV augmentation with exercise; no exercise-induced arrhythmias Return to play
25 Yes PCR No No Yes Decreased GLS No CMR evidence of myocarditis Normal LV augmentation with exercise; no exercise-induced arrhythmias Return to play
26 Yes PCR No Yes No NA No CMR evidence of myocarditis Normal LV augmentation with exercise; no exercise-induced arrhythmias Return to play
27 Yes PCR No Yes Yes Decreased GLS No CMR evidence of myocarditis Normal LV augmentation with exercise; no exercise-induced arrhythmias Return to play
28 Yes PCR No Yes Yes New regional wall motion abnormality in comparison with prior echocardiographic studies; preserved LVEF Normal LVEF; LGE present in corresponding territory as echocardiogram; CMR findings consistent with myocarditis NA Held out
29 Yes PCR No No Yes Dilated right ventricle Normal LVEF and RV systolic function; focal T2 hyperintensity in the mid-ventricular inferior wall; CMR findings consistent with myocarditis NA Held out
30 Yes PCR No Yes No NA No CMR evidence of myocarditis NA Return to play

Abbreviations: CMR, cardiac magnetic resonance imaging; COVID-19, coronavirus disease 2019; ECG, electrocardiogram; echo, echocardiogram; GLS, global longitudinal strain; LGE, late gadolinium enhancement; LV, left ventricle; LVEF, left ventricular ejection fraction; NA, not applicable; PCR, polymerase chain reaction; PVC, premature ventricular contractions.

a

There were 4 women and 26 men ranging in age from 19 to 35 years. Age and sex are not specified for each athlete in this table to maintain confidentiality.

b

Abnormal troponin levels were defined as those greater than the 99th percentile upper limit of normal.

c

An abnormal ECG was defined as a new ECG abnormality meeting international recommendations9 and demonstrating findings raising concern for potential acute cardiac injury.

d

An abnormal echocardiogram was defined as new ventricular dysfunction or another echocardiographic finding raising concern for potential acute cardiac injury.

e

Following American Heart Association/American College of Cardiology myocarditis or pericarditis guidelines.10