FIGURE 2.

Differential lipid species were associated with fatty acid metabolism. (A) Lipid metabolic networks were constructed by using Cytoscape, Reactome, KEGG and NetPath. Adenine-induced CRF were mainly associated with fatty acid metabolism, arachidonic acid metabolism. (B) Lipid metabolite sets enrichment overview including α-linolenic acid and linoleic acid metabolism, arachidonic acid metabolism, glycerolipid metabolism, fatty acid elongation in mitochondria, fatty acid biosynthesis, fatty acid metabolism, steroid biosynthesis and bile acid biosynthesis. The size and color of each circle is based on enrichment ratio and p-values, respectively. Enrichment ratio is computed by hits/expected, where hits indicates observed hits; expected indicates expected hits.