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. 2021 Mar 4;21:153. doi: 10.1186/s12935-021-01855-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The expression level of circCSPP1 in DOX-resistant tissues and cells. a The expression level of circCSPP1 was detected by qRT-PCR in DOX-resistant or DOX-sensitive CRC tissues. b, c The DOX-resistant CRC LoVo/DOX (b) and HCT116/DOX (c) cells were analyzed by MTT assay. IC50 of 24 h was shown. d The expression of circCSPP1 was examined by qRT-PCR in LoVo/DOX and HCT116/DOX cells as well as in LoVo and HCT116 cells. *P < 0.05