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. 2021 Mar 4;21:152. doi: 10.1186/s12935-021-01853-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — A Various morphologies of MCTs depending on cancer cell lines. Compact MCTs were generated with (a) MCF-7, (b) BT-474, (c) T-47D, and (d) MDA-MB-361. (e) MDA-MB-435S cells aggregated tightly but 3 cell lines of (f) MDA-MB-231, (g) MDA-MB-468, and (h) SK-BR-3 aggregated loosely. Adding 2.5% rBM yielded significant compaction (e'–h'). Bar: 500 μm. Reproduced with permission [22].

Copyright 2007, Demetrios Spandidos. B Honeycomb concave microwell. (a) Schematic diagram of a honeycomb concave microwell array (width [W], diameter [D], wall thickness [T]). (b) Various sizes of the honeycomb concave microwell chambers. (c) MCTs formation in the circular and honeycomb concave microwells. Bar: 500 μm. (d) The evaluation of hepatocyte spheroids in 2 different concave microwells [84]. Copyright 2016, Permits unrestricted use. C (a) Illustration of MCTs formation. (b) HCT-116 MCTs size as a function of sheet growth time. The sizes were recorded on different shaking days (days 3, 5, 7, and 9). (c) MCTs size as a function of culturing time with different initial cell seeding density [86]. Copyright 2018, Springer Nature